Well, sorta. Off The Wall isn't my only comic. It's not even my first comic (that one, called Charlie, was way back in the pre-Internet days). But it's the only one I've continued with for any appreciable amount of time. For some inexplicable reason, I keep coming back to it.
That said, there are two comics that I did for a time: Freshman and I've Got A Nickel. They ended for mundane reasons, but it wasn't actually for a lack of desire or effort. For the betterment of all mankind, here they are in all their glory.